Effects of synbiotic food consumption on glycemic status and serum hs-CRP in pregnant women: a randomized controlled clinical trial
Assessed by RV013 · Clinical Chair in Health Services Research
Assessed on 12 Nov 2025
OverallReviewer's overall integrity assessment, derived from all research questions Serious concerns
Resource ripekg:research-integrity-assessment/RIPEAF6AAC41E3D64BA2C
5 Research Questions · 36 Evidence Items
Q1.1 — Does the study have an associated retraction?
Rationale: Agree. For reference without doi, there's a doi on PubMed
Supporting Evidence (2)
Retraction NoticeSource: Retraction Watch database
Effects of synbiotic food consumption on metabolic status of diabetic patients: a double-blind randomized cross-over controlled clinical trial
10.1016/j.clnu.2025.08.016 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 67323
Rationale: Concerns/Issues About Data;Concerns/Issues about Results and/or Conclusions;Investigation by Journal/Publisher;Investigation by Third Party;Objections by Author(s);Unreliable Results and/or Conclusions
About Authors: Zatollah Asemi, Ahmad Esmaillzadeh
Retraction NoticeSource: Retraction Watch database
Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice
10.1371/journal.pbio.1002479 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 1996
Rationale: Duplication of/in Image;Error in Image;Investigation by Company/Institution;Investigation by Journal/Publisher
Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?
Rationale: Agree, yes.
Supporting Evidence (1)
Expression of ConcernSource: Retraction Watch database
Effects of synbiotic food consumption on glycemic status and serum hs-CRP in pregnant women: a randomized controlled clinical trial
10.1007/s42000-022-00349-y (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 42952
Rationale: Concerns/Issues About Data;Concerns/Issues about Results and/or Conclusions;Ethical Violations by Author;Investigation by Third Party
Q1.3 — Do other studies by the research team highlight causes for concern?
Rationale: Multiple entries on RW database
Supporting Evidence (31)
Retraction NoticeSource: Retraction Watch database
The effects of omega-3 fatty acids from flaxseed oil on genetic and metabolic profiles in patients with gestational diabetes mellitus: a randomized, double-blind, placebo-controlled trial
10.1017/s0007114521004037 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 43692
Rationale: Investigation by Journal/Publisher;Notice - Limited or No Information
About Authors: Mohsen Taghizadeh, Mehri Jamilian, Elaheh Amirani, Zohreh Tabassi, Mohammad Memarzadeh, Esmat Aghadavod, Mohammad Mansournia
Retraction NoticeSource: Retraction Watch database
Probiotic supplementation and the effects on weight loss, glycaemia and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial
10.1080/14647273.2024.2373595 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 54767
Rationale: Concerns/Issues About Data;Concerns/Issues about Results and/or Conclusions;Concerns/Issues about Referencing/Attributions;Investigation by Journal/Publisher;Investigation by Third Party;Objections by Author(s);Unreliable Results and/or Conclusions;Upgrade/Update of Prior Notice(s)
About Authors: Mohsen Taghizadeh, Zatollah Asemi, Mehri Jamilian, Maryam Tajabadi-Ebrahimi, Maryam Karamali, Mohammad Memarzadeh
Retraction NoticeSource: Retraction Watch database
Effect of daily consumption of probiotic yoghurt on lipid profiles in pregnant women: a randomized controlled clinical trial
10.1080/14767058.2024.2364976 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 67044
Rationale: Concerns/Issues About Data;Concerns/Issues about Results and/or Conclusions;Investigation by Journal/Publisher;Investigation by Third Party;Objections by Author(s);Unreliable Results and/or Conclusions;Upgrade/Update of Prior Notice(s)
About Authors: Zatollah Asemi, Ahmad Esmaillzadeh
Q2.2 — Are there concerns relating to the timing or absence of study registration?
Rationale: Agree, very late registration. Mention of rule 5 in text not needed.
Supporting Evidence (2)
Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)
Registration ID: IRCT201212105623N3
Registry: IRCT
Registry Link: https://trialsearch.who.int/Trial2.aspx?TrialID=IRCT201212105623N3 (opens in new tab)
Registration Date: 26 Dec 2012
Prospective:Whether the trial was registered before participant recruitment began No
Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates Comparison performed at month level. Registration: 2012-12, LLM Recruitment Start: 2012-06. Deemed retrospective at month level.
Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text
Recruitment Start: 06-2012
Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date Methods: 'This randomized placebo-controlled clinical trial was performed in Kashan, Iran, from June 2012 to February 2013'; using the start date of the trial as the recruitment start date per rule 5.
Recruitment End: N/A
Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date No explicit recruitment end date found.
Study End: 02-2013
Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date Methods: 'This randomized placebo-controlled clinical trial was performed in Kashan, Iran, from June 2012 to February 2013'; using the end date of the trial as the study end date per rule 5.
Overall — What is the overall integrity assessment of the study?
Rationale: Consistent with serious concerns