Therapeutic effects of curcumin and piperine combination in critically ill patients with sepsis: a randomized double-blind controlled trial
Assessed by RV013 · Clinical Chair in Health Services Research
Assessed on 10 Nov 2025
OverallReviewer's overall integrity assessment, derived from all research questions Serious concerns
DOI 10.1186/s13063-025-08916-5 (opens in new tab)
Resource ripekg:research-integrity-assessment/RIPEABEA90C1082270AFB
5 Research Questions · 10 Evidence Items
Q1.1 — Does the study have an associated retraction?
Rationale: Agree, no retraction including on journal website.
Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?
Rationale: Agree, no notice on PubPeer or journal page
Q1.3 — Do other studies by the research team highlight causes for concern?
Rationale: Agree, 2 authors with retractions, one with 7 retractions
Supporting Evidence (8)
Retraction NoticeSource: Retraction Watch database
Therapeutic effect of nanoliposomal PCSK9 vaccine in a mouse model of atherosclerosis
10.1186/s12916-023-02884-w (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 44538
Rationale: Manipulation of Images;Original Data and/or Images not Provided and/or not Available;Unreliable Data
About Author: Amirhossein Sahebkar
Retraction NoticeSource: Retraction Watch database
Synthesis, characterization and cytotoxicity evaluation of a novel magnetic nanocomposite with iron oxide deposited on cellulose nanofibers with nickel (Fe3O4@NFC@ONSM-Ni)†
10.1039/d3ra90131a (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 50790
Rationale: Concerns/Issues about Third Party Involvement;Duplication of Data;Duplication of/in Image;Unreliable Data;Unreliable Results and/or Conclusions
About Author: Zahra Kiani
Retraction NoticeSource: Retraction Watch database
The therapeutic potential of human adipose-derived mesenchymal stem cells producing CXCL10 in a mouse melanoma lung metastasis model
10.1016/j.canlet.2024.216670 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 51535
Rationale: Duplication of/in Image;Investigation by Journal/Publisher;Investigation by Third Party;Original Data and/or Images not Provided and/or not Available;Unreliable Results and/or Conclusions
About Author: Amirhossein Sahebkar
Q2.2 — Are there concerns relating to the timing or absence of study registration?
Rationale: Agree prospective registration. Some labelling of US/UK date formats would be useful.
Supporting Evidence (2)
Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)
Registration ID: IRCT20150613022681N4
Registry: IRCT
Registry Link: https://trialsearch.who.int/Trial2.aspx?TrialID=IRCT20150613022681N4 (opens in new tab)
Registration Date: 2 Jan 2021
Prospective:Whether the trial was registered before participant recruitment began Yes
Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates Comparison performed at month level. Registration: 2021-01, LLM Recruitment Start: 2021-02. Deemed prospective at month level.
Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text
Recruitment Start: 02-2021
Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date The study was conducted from Feb 2021 (start of recruitment) to May 2022.
Recruitment End: N/A
Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date No explicit end-of-recruitment date found after full search.
Study End: 05-2022
Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date The study was conducted from Feb 2021 to May 2022 (end of study).
Overall — What is the overall integrity assessment of the study?
Rationale: Overall serious concerns relating to 2 authors with retractions, one with 7.