Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome
Assessed by RV016 · Research Manager/Fellow
Assessed on 20 Nov 2025
OverallReviewer's overall integrity assessment, derived from all research questions Serious concerns
DOI 10.1055/s-0035-1559604 (opens in new tab)
Resource ripekg:research-integrity-assessment/RIPEA9DB33DAF95B0A027
5 Research Questions · 3 Evidence Items
Q1.1 — Does the study have an associated retraction?
Rationale: No rationale provided
Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?
Rationale: Yes it has a post publication notice
Supporting Evidence (1)
PubPeer ThreadSource: PubPeer.com — post-publication peer review comments
https://pubpeer.com/publications/3BD4DE5C1C807347CBC0242CE568CF (opens in new tab)PubPeer CommentSource: PubPeer.com — a platform for post-publication peer review
There are many concerns about the integrity of 172 publications by this research group, including this one. Some of the concerns are published 1. Anaesthesia 2020;75:1683–92, see Supplementary data. This paper is A72 2. Account Res 2020;28:149-61. 3. J Clin Epidemiol 2021;131:22-29. Journals and publishers were notified of these concerns in July 2019. 23 publications have an expression of concern. To our knowledge there has been no public response about any of the concerns. We think these publications are unreliable
Thread: https://pubpeer.com/publications/3BD4DE5C1C807347CBC0242CE568CF (opens in new tab)
Q1.3 — Do other studies by the research team highlight causes for concern?
Rationale: The post-publication notice does evidences pubpeer expressing concern about the research integrity of publications by this research team.
Q2.2 — Are there concerns relating to the timing or absence of study registration?
Rationale: Yes it is after recruitment has finished
Supporting Evidence (2)
Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)
Registration ID: IRCT201412295623N33
Registry: IRCT
Registry Link: https://trialsearch.who.int/Trial2.aspx?TrialID=IRCT201412295623N33 (opens in new tab)
Registration Date: 9 Jan 2015
Prospective:Whether the trial was registered before participant recruitment began No
Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates Comparison performed at month level. Registration: 2015-01, LLM Recruitment Start: 2014-10. Deemed retrospective at month level.
Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text
Recruitment Start: 10-2014
Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date Methods: 'from October 2014' was used as recruitment start date, no specific date found.
Recruitment End: 12-2014
Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date Methods: 'to December 2014' was used as recruitment finish date, no specific date found.
Study End: N/A
Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date No explicit study end date found after a full search.
Overall — What is the overall integrity assessment of the study?
Rationale: Serious concerns given the post recruitment registration and the notice of concern