Comparison of AI-assisted and human-generated plain language summaries for Cochrane reviews: a randomised non-inferiority trial (HIET-1) [Registered Report - stage II]

Assessed by RV019 · Evidence Synthesis Methdos Lead

Assessed on 8 Mar 2026

OverallReviewer's overall integrity assessment, derived from all research questions No concerns

DOI 10.1016/j.jclinepi.2025.112102 (opens in new tab)

Resource ripekg:research-integrity-assessment/RIPEA70EC0A9869D3B68A

5 Research Questions · 3 Evidence Items

Q1.1 — Does the study have an associated retraction?

Automated Assessment:Assessment produced by the automated systemNo

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsN/A

Rationale: No rationale provided

Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?

Automated Assessment:Assessment produced by the automated systemNo

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsN/A

Rationale: No rationale provided

Q1.3 — Do other studies by the research team highlight causes for concern?

Automated Assessment:Assessment produced by the automated systemYes

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsNo

Rationale: This is another author named "James Thomas". The affiliations are different.

Supporting Evidence (1)

Retraction NoticeSource: Retraction Watch database

Genomic Instability in Liver Cells Caused by an LPS-Induced Bystander-Like Effect

10.1371/journal.pone.0276208

Journal: PLoS OnePublisher: PLoSDate: 10 Oct 2022

RetractionWatch ID:Record identifier in the Retraction Watch database 39798

Rationale: Concerns/Issues about Results and/or Conclusions

About Author: James Thomas

Retracts: 10.1371/journal.pone.0067342

Q2.2 — Are there concerns relating to the timing or absence of study registration?

Automated Assessment:Assessment produced by the automated systemUnclear

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsNo

Rationale: No rationale provided

Supporting Evidence (2)

Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)

Registration ID: ISRCTN85699985

Registry: ISRCTN

Registry Link: https://trialsearch.who.int/Trial2.aspx?TrialID=ISRCTN85699985 (opens in new tab)

Registration Date: 2 Apr 2025

Prospective:Whether the trial was registered before participant recruitment began No

Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates LLM-extracted recruitment start date (normalized_date) is missing or empty.

Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text

Recruitment Start: N/A

Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date No recruitment start date found.

Recruitment End: N/A

Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date No recruitment finish date found.

Study End: N/A

Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date Accepted 7 December 2025; Published online 15 December 2025. No explicit study end date found; publication dates are not used.

Overall — What is the overall integrity assessment of the study?

Automated Assessment:Assessment produced by the automated systemN/A

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsNo concerns

Rationale: No rationale provided