Effects of intravaginal conjugated oestrogen on pessary continuation for pelvic organ prolapse: multicentre, randomised, double blind, placebo controlled trial
Assessed by RV013 · Clinical Chair in Health Services Research
Assessed on 16 Nov 2025
OverallReviewer's overall integrity assessment, derived from all research questions Some concerns
DOI 10.1136/bmj-2025-084418 (opens in new tab)
Resource ripekg:research-integrity-assessment/RIPEA61C486302F135B42
5 Research Questions · 93 Evidence Items
Q1.1 — Does the study have an associated retraction?
Rationale: No webpage notice.
Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?
Rationale: No webpage notice.
Q1.3 — Do other studies by the research team highlight causes for concern?
Rationale: Authors's names on RW need institutions checked.
Supporting Evidence (91)
Retraction NoticeSource: Retraction Watch database
Alterations in the Endometrium of Rats, Rabbits, and Macaca mulatta that Received an Implantation of Copper/Low-Density Polyethylene Nanocomposite
10.2147/ijn.s451965 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 50048
Rationale: Concerns/Issues About Image;Duplication of/in Image;Error in Image;Investigation by Journal/Publisher;Original Data and/or Images not Provided and/or not Available;Unreliable Results and/or Conclusions
About Authors: Jing Yang, Hong Wang
Retraction NoticeSource: Retraction Watch database
Overexpression of the Arabidopsis ASYMMERTIC LEAVES2-LIKE11 gene in Cockscomb leads to modification of flowering and lateral branching
10.1007/s11240-010-9733-5 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 16016
Rationale: Concerns/Issues About Authorship/Affiliation;Concerns/Issues about Third Party Involvement;Objections by Author(s)
About Author: Ying Zhou
Retraction NoticeSource: Retraction Watch database
Interactions between Th1 cells and Tregs affect regulation of hepatic fibrosis in biliary atresia through the IFN-gamma/STAT1 pathway
10.1038/s41418-019-0428-0 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 21359
Rationale: Concerns/Issues About Data;Concerns/Issues About Image;Duplication of/in Image
About Author: Ying Zhou
Q2.2 — Are there concerns relating to the timing or absence of study registration?
Rationale: Registration and recruitment started in same month.
Supporting Evidence (2)
Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)
Registration ID: NCT04393194
Registry: ClinicalTrials.gov
Registry Link: https://clinicaltrials.gov/study/NCT04393194 (opens in new tab)
Registration Date: 13-05-2020
Prospective:Whether the trial was registered before participant recruitment began Yes
Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates Comparison performed at month level. Registration: 2020-05, LLM Recruitment Start: 2020-05. Deemed prospective at month level.
Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text
Recruitment Start: 05-2020
Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date Setting: 'May 2020-June 2023'; no specific FPI date found, so using start of recruitment range.
Recruitment End: N/A
Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date No explicit LPI date found.
Study End: 06-2023
Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date Setting: 'May 2020-June 2023'; no specific study end date found, so using end of recruitment range.
Overall — What is the overall integrity assessment of the study?
Rationale: Authors' institutions need checking.