Changes in the anticitrullinated peptide antibody response in relation to therapeutic outcome in early rheumatoid arthritis: results from the SWEFOT trial
Assessed by RV017 · Evidence Synthesis Methodolodgy Editor
Assessed on 4 Mar 2026
OverallReviewer's overall integrity assessment, derived from all research questions No concerns
DOI 10.1136/annrheumdis-2014-205698 (opens in new tab)
Resource ripekg:research-integrity-assessment/RIPEA4875E56C8C5C4ACF
5 Research Questions · 3 Evidence Items
Q1.1 — Does the study have an associated retraction?
Rationale: No retraction on journal website.
Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?
Rationale: Nothing identified.
Q1.3 — Do other studies by the research team highlight causes for concern?
Rationale: One author has a retraction in Retraction Watch. This study was retracted by the author team themselves after finding an error in the way the outcomes were measured - not seen as related to research integrity. None of the other authors have any retractions.
Supporting Evidence (1)
Retraction NoticeSource: Retraction Watch database
Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition
10.1084/jem.2012148612112018r (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 19710
Rationale: Error in Analyses;Error in Methods;Results Not Reproducible
About Author: Lars Klareskog
Q2.2 — Are there concerns relating to the timing or absence of study registration?
Rationale: Details of recruitment aren't captured in the trial registry or in the publication. The only dates given in the trial registry are: study start date: 2002-12 and study completion date: 2008-12. Unknown when recruitment took place but likely the trial was registered prospectively. No immediate concerns.
Supporting Evidence (2)
Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)
Registration ID: NCT00764725
Registry: ClinicalTrials.gov
Registry Link: https://clinicaltrials.gov/study/NCT00764725 (opens in new tab)
Registration Date: 01-10-2008
Prospective:Whether the trial was registered before participant recruitment began No
Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates LLM-extracted recruitment start date (normalized_date) is missing or empty.
Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text
Recruitment Start: N/A
Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date No recruitment start date found after a full search of the document.
Recruitment End: N/A
Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date No recruitment end date found after a full search of the document.
Study End: N/A
Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date No study end date found after a full search of the document.
Overall — What is the overall integrity assessment of the study?
Rationale: No concerns with this study.