Prevention of acute myocardial infarction induced heart failure by intracoronary infusion of mesenchymal stem cells: phase 3 randomised clinical trial (PREVENT-TAHA8)

Assessed by RV018 · Methods Support Unit Manager

Assessed on 18 Feb 2026

OverallReviewer's overall integrity assessment, derived from all research questions Serious concerns

DOI 10.1136/bmj-2024-083382 (opens in new tab)

Resource ripekg:research-integrity-assessment/RIPEA44677276976C010D

5 Research Questions · 2 Evidence Items

Q1.1 — Does the study have an associated retraction?

Automated Assessment:Assessment produced by the automated systemNo

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsNo

Rationale: No rationale provided

Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?

Automated Assessment:Assessment produced by the automated systemNo

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsYes

Rationale: AI check did not pick up the Expression of Concern, and the PubPeer search failed

Q1.3 — Do other studies by the research team highlight causes for concern?

Automated Assessment:Assessment produced by the automated systemNo

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsNo

Rationale: No rationale provided

Q2.2 — Are there concerns relating to the timing or absence of study registration?

Automated Assessment:Assessment produced by the automated systemNo

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsNo

Rationale: No rationale provided

Supporting Evidence (2)

Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)

Registration ID: NCT05043610

Registry: ClinicalTrials.gov

Registry Link: https://clinicaltrials.gov/study/NCT05043610 (opens in new tab)

Registration Date: 06-09-2021

Prospective:Whether the trial was registered before participant recruitment began Yes

Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates Comparison performed at month level. Registration: 2021-09, LLM Recruitment Start: 2021-09. Deemed prospective at month level.

Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text

Recruitment Start: 09-2021

Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date Methods: 'September 2021' is the start date for when the trial was conducted.

Recruitment End: 11-2022

Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date Methods: 'November 2022' is the end date for when the trial was conducted, but it is not a recruitment end date.

Study End: 10-2024

Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date Methods: 'October 2024' is the end date for when the trial was conducted.

Overall — What is the overall integrity assessment of the study?

Automated Assessment:Assessment produced by the automated systemN/A

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsSerious concerns

Rationale: Serious concerns because of the Expression of Concern