Self-compassion mediates treatment effects in MDMA-assisted therapy for posttraumatic stress disorder

Assessed by RV017 · Evidence Synthesis Methodolodgy Editor

Assessed on 25 Feb 2026

OverallReviewer's overall integrity assessment, derived from all research questions Some concerns

DOI 10.1080/20008066.2025.2485513 (opens in new tab)

Resource ripekg:research-integrity-assessment/RIPEA3DD73E2311E591AF

5 Research Questions · 2 Evidence Items

Q1.1 — Does the study have an associated retraction?

Automated Assessment:Assessment produced by the automated systemNo

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsNo

Rationale: No retraction on journal website.

Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?

Automated Assessment:Assessment produced by the automated systemNo

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsNo

Rationale: No expression of concern or PubPeer comments.

Q1.3 — Do other studies by the research team highlight causes for concern?

Automated Assessment:Assessment produced by the automated systemNo

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsNo

Rationale: No mentions in Retraction Watch.

Q2.2 — Are there concerns relating to the timing or absence of study registration?

Automated Assessment:Assessment produced by the automated systemYes

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsYes

Rationale: Registration occurred in May 2018 but recruitment start date was March 2018 so this was retrospectively registered. Not clear when recruitment ended.

Supporting Evidence (2)

Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)

Registration ID: NCT03537014

Registry: ClinicalTrials.gov

Registry Link: https://clinicaltrials.gov/study/NCT03537014 (opens in new tab)

Registration Date: 24-05-2018

Prospective:Whether the trial was registered before participant recruitment began No

Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates Comparison performed at month level. Registration: 2018-05, LLM Recruitment Start: 2018-03. Deemed retrospective at month level.

Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text

Recruitment Start: 03-2018

Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date Results: 'Participants were recruited from 2018 to 2020'; no specific FPI elsewhere.

Recruitment End: N/A

Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date No explicit end-of-recruitment date after full search; range end is not used for recruitment_finish.

Study End: N/A

Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date Results: 'Participants were recruited from 2018 to 2020'; no specific completion date.

Overall — What is the overall integrity assessment of the study?

Automated Assessment:Assessment produced by the automated systemN/A

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsSome concerns

Rationale: Potential concern with trial registration occurring two months after recruitment started.