Eff ectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a randomised controlled trial
Assessed by RV011 · Statistician
Assessed on 17 Nov 2025
OverallReviewer's overall integrity assessment, derived from all research questions No concerns
Resource ripekg:research-integrity-assessment/RIPEA3B4591B6CF8537BB
5 Research Questions · 2 Evidence Items
Q1.1 — Does the study have an associated retraction?
Rationale: There are no retractions.
Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?
Rationale: I had uploaded an older version of the paper without a DOI. I have checked online and there is no expression of concern.
Q1.3 — Do other studies by the research team highlight causes for concern?
Rationale: No concerns with any other studies by the authors.
Q2.2 — Are there concerns relating to the timing or absence of study registration?
Rationale: The registration was done in 2008, so no concerns.
Supporting Evidence (2)
Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)
Registration ID: ISRCTN44464607
Registry: ISRCTN
Registry Link: https://trialsearch.who.int/Trial2.aspx?TrialID=ISRCTN44464607 (opens in new tab)
Registration Date: 23/10/2008
Prospective:Whether the trial was registered before participant recruitment began Yes
Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates Registration date is on or before LLM recruitment start date.
Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text
Recruitment Start: 08-01-2009
Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date Methods: 'From Jan 8, 2009, to Dec 28, 2011, we enrolled patients...'.
Recruitment End: 28-12-2011
Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date Methods: 'From Jan 8, 2009, to Dec 28, 2011, we enrolled patients...'.
Study End: N/A
Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date Results: The final visit was held in December, 2014, but this is not the study end date. No explicit study end date found.
Overall — What is the overall integrity assessment of the study?
Rationale: I agree that there are no concerns with the study.