The PUrE randomised controlled trial 1: Clinical and cost effectiveness of flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole stones of ≤10 mm
Assessed by RV002 · Business Manager
Assessed on 3 Nov 2025
OverallReviewer's overall integrity assessment, derived from all research questions No concerns
DOI 10.1016/j.eururo.2025.02.002 (opens in new tab)
Resource ripekg:research-integrity-assessment/RIPEA329F4FA34B918A26
5 Research Questions · 2 Evidence Items
Q1.1 — Does the study have an associated retraction?
Rationale: Agree - no retraction found
Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?
Rationale: Agree - no comments etc found
Q1.3 — Do other studies by the research team highlight causes for concern?
Rationale: Agree - none of the authors found on Retraction Watch
Q2.2 — Are there concerns relating to the timing or absence of study registration?
Rationale: Agree - trial was registered well in advance of recruitment starting
Supporting Evidence (2)
Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)
Registration ID: ISRCTN92289221
Registry: ISRCTN
Registry Link: https://trialsearch.who.int/Trial2.aspx?TrialID=ISRCTN92289221 (opens in new tab)
Registration Date: 21/02/2013
Prospective:Whether the trial was registered before participant recruitment began Yes
Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates Registration date is on or before LLM recruitment start date.
Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text
Recruitment Start: 09-05-2016
Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date Results: 'Between May 9, 2016 and March 31, 2021, 232 and 234 participants were recruited and randomised to the FURS and ESWL arms, respectively.'
Recruitment End: 31-03-2021
Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date Results: 'Between May 9, 2016 and March 31, 2021, 232 and 234 participants were recruited and randomised to the FURS and ESWL arms, respectively.'
Study End: N/A
Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date No explicit study end date found. The follow-up was until 12 mo following randomisation or 12 wk following intervention, whichever was later.
Overall — What is the overall integrity assessment of the study?
Rationale: No concerns found