Flaxseed Oil Supplementation Improve Gene Expression Levels of PPAR‐γ, LP(a), IL‐1 and TNF‐α in Type 2 Diabetic Patients with Coronary Heart Disease
Assessed by RV019 · Evidence Synthesis Methdos Lead
Assessed on 8 Mar 2026
OverallReviewer's overall integrity assessment, derived from all research questions Serious concerns
DOI 10.1007/s11745-017-4295-5 (opens in new tab)
Resource ripekg:research-integrity-assessment/RIPEA323E9769EC8E8E48
5 Research Questions · 55 Evidence Items
Q1.1 — Does the study have an associated retraction?
Rationale: No rationale provided
Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?
Rationale: No rationale provided
Supporting Evidence (1)
PubPeer ThreadSource: PubPeer.com — post-publication peer review comments
https://pubpeer.com/publications/E8FE4BCC719A4153D260491E83627D (opens in new tab)PubPeer CommentSource: PubPeer.com — a platform for post-publication peer review
There are many concerns about the integrity of 172 publications by this research group, including this one. Some of the concerns are published 1. Anaesthesia 2020;75:1683–92, see Supplementary data. This paper is A91 2. Account Res 2020;28:149-61. 3. J Clin Epidemiol 2021;131:22-29. Journals and publishers were notified of these concerns in July 2019. 23 publications have an expression of concern. To our knowledge there has been no public response about any of the concerns. We think these publications are unreliable
Thread: https://pubpeer.com/publications/E8FE4BCC719A4153D260491E83627D (opens in new tab)
Q1.3 — Do other studies by the research team highlight causes for concern?
Rationale: No rationale provided
Supporting Evidence (52)
Retraction NoticeSource: Retraction Watch database
The Effect of Zinc Supplementation on Expressed Levels of Peroxisome Proliferator-Activated Receptor Gamma and Glucose Transporter Type 1 Genes in Newborns of Women with Gestational Diabetes Mellitus
10.1007/s12011-016-0788-y (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 28454
Rationale: Concerns/Issues About Data;Investigation by Company/Institution;Updated to Retraction
About Authors: Mehri Jamilian, Mansooreh Samimi, Esmat Aghadavod
Retraction NoticeSource: Retraction Watch database
Effects of Selenium Supplementation on Gene Expression Levels of Inflammatory Cytokines and Vascular Endothelial Growth Factor in Patients with Gestational Diabetes
10.1007/s12011-017-1045-8 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 28465
Rationale: Concerns/Issues About Data;Investigation by Company/Institution
About Authors: Mehri Jamilian, Mansooreh Samimi, Esmat Aghadavod, Faraneh Afshar Ebrahimi
Retraction NoticeSource: Retraction Watch database
The Effect of Zinc Supplementation on Expressed Levels of Peroxisome Proliferator-Activated Receptor Gamma and Glucose Transporter Type 1 Genes in Newborns of Women with Gestational Diabetes Mellitus
10.1007/s12011-022-03501-2 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 40895
Rationale: Concerns/Issues About Data;Concerns/Issues About Image;Concerns/Issues about Referencing/Attributions;Duplication of/in Article;Investigation by Company/Institution;Unreliable Results and/or Conclusions;Upgrade/Update of Prior Notice(s)
About Authors: Mehri Jamilian, Mansooreh Samimi, Esmat Aghadavod
Q2.2 — Are there concerns relating to the timing or absence of study registration?
Rationale: No rationale provided
Supporting Evidence (2)
Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)
No trial registration found
Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates Registry registration date (study_first_submit_qc_date) is missing or empty.
Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text
Recruitment Start: 01-2017
Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date The study was conducted between January 2017 and April 2017. Using the start of the range as the recruitment start date per rule 5.
Recruitment End: N/A
Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date No explicit recruitment end date found.
Study End: 04-2017
Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date The study was conducted between January 2017 and April 2017. Using the end of the range as the study end date per rule 5.
Overall — What is the overall integrity assessment of the study?
Rationale: No rationale provided