Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: a randomized-controlled trial
Assessed by RV013 · Clinical Chair in Health Services Research
Assessed on 2 Mar 2026
OverallReviewer's overall integrity assessment, derived from all research questions Some concerns
DOI 10.1007/s00394-018-1760-8 (opens in new tab)
Resource ripekg:research-integrity-assessment/RIPEA2D3EB3B0F74C441B
5 Research Questions · 3 Evidence Items
Q1.1 — Does the study have an associated retraction?
Rationale: No rationale provided
Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?
Rationale: No rationale provided
Q1.3 — Do other studies by the research team highlight causes for concern?
Rationale: Correction made to another article due to errors in measuring 25OHD.
Supporting Evidence (1)
Retraction NoticeSource: Retraction Watch database
Patients with polymorphic light eruption have decreased serum levels of 25-hydroxyvitamin-D3 that increase upon 311 nm UVB photohardening
10.1039/c5pp90044a (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 8929
Rationale: Error in Methods;Unreliable Results and/or Conclusions
About Author: Barbara Obermayer-Pietsch
Q2.2 — Are there concerns relating to the timing or absence of study registration?
Rationale: EuDRACT number registered in 2011
Supporting Evidence (2)
Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)
Registration ID: NCT01721915
Registry: ClinicalTrials.gov
Registry Link: https://clinicaltrials.gov/study/NCT01721915 (opens in new tab)
Registration Date: 02-11-2012
Prospective:Whether the trial was registered before participant recruitment began No
Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates Comparison performed at month level. Registration: 2012-11, LLM Recruitment Start: 2011-12. Deemed retrospective at month level.
Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text
Recruitment Start: 12-2011
Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date Methods: 'This study was a single-center, double-blind, randomized placebo-controlled trial conducted between December 2011 and July 2017 at the Medical University of Graz, Austria.' Used start of conducted range as recruitment_start per rule 5; no specific FPI elsewhere.
Recruitment End: N/A
Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date No explicit end-of-recruitment date after full search.
Study End: 07-2017
Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date Methods: 'This study was a single-center, double-blind, randomized placebo-controlled trial conducted between December 2011 and July 2017 at the Medical University of Graz, Austria.' Used end of conducted range as study_end_date per rule 5; no specific completion date.
Overall — What is the overall integrity assessment of the study?
Rationale: Some concerns with one author, also real start date of trial, although prospective registration.