The effects of omega-3 and vitamin E co-supplementation on parameters of mental health and gene expression related to insulin and inflammation in subjects with polycystic ovary syndrome
Assessed by RV003 · Research Fellow
Assessed on 30 Oct 2025
OverallReviewer's overall integrity assessment, derived from all research questions Serious concerns
DOI 10.1016/j.jad.2017.12.049 (opens in new tab)
Resource ripekg:research-integrity-assessment/RIPEA0C83AF9CE6274D42
5 Research Questions · 74 Evidence Items
Q1.1 — Does the study have an associated retraction?
Rationale: No rationale provided
Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?
Rationale: Integrity of research group questioned
Supporting Evidence (1)
PubPeer ThreadSource: PubPeer.com — post-publication peer review comments
https://pubpeer.com/publications/C62B49583B9C8562841A1222791F65 (opens in new tab)PubPeer CommentSource: PubPeer.com — a platform for post-publication peer review
There are many concerns about the integrity of 172 publications by this research group, including this one. Some of the concerns are published 1. Anaesthesia 2020;75:1683–92, see Supplementary data. This paper is A140 2. Account Res 2020;28:149-61. 3. J Clin Epidemiol 2021;131:22-29. Journals and publishers were notified of these concerns in July 2019. 18 publications have an expression of concern, and 6 have been retracted. To our knowledge there has been no public response about any of the concerns. We think these publications are unreliable
Thread: https://pubpeer.com/publications/C62B49583B9C8562841A1222791F65 (opens in new tab)
Q1.3 — Do other studies by the research team highlight causes for concern?
Rationale: A number of mentions for 9 authors
Supporting Evidence (71)
Retraction NoticeSource: Retraction Watch database
The Effect of Zinc Supplementation on Expressed Levels of Peroxisome Proliferator-Activated Receptor Gamma and Glucose Transporter Type 1 Genes in Newborns of Women with Gestational Diabetes Mellitus
10.1007/s12011-016-0788-y (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 28454
Rationale: Concerns/Issues About Data;Investigation by Company/Institution;Updated to Retraction
About Authors: Mehri Jamilian, Mansooreh Samimi, Esmat Aghadavod
Retraction NoticeSource: Retraction Watch database
Effects of Selenium Supplementation on Gene Expression Levels of Inflammatory Cytokines and Vascular Endothelial Growth Factor in Patients with Gestational Diabetes
10.1007/s12011-017-1045-8 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 28465
Rationale: Concerns/Issues About Data;Investigation by Company/Institution
About Authors: Mehri Jamilian, Mansooreh Samimi, Esmat Aghadavod, Faraneh Afshar Ebrahimi
Retraction NoticeSource: Retraction Watch database
The Effect of Zinc Supplementation on Expressed Levels of Peroxisome Proliferator-Activated Receptor Gamma and Glucose Transporter Type 1 Genes in Newborns of Women with Gestational Diabetes Mellitus
10.1007/s12011-022-03501-2 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 40895
Rationale: Concerns/Issues About Data;Concerns/Issues About Image;Concerns/Issues about Referencing/Attributions;Duplication of/in Article;Investigation by Company/Institution;Unreliable Results and/or Conclusions;Upgrade/Update of Prior Notice(s)
About Authors: Mehri Jamilian, Mansooreh Samimi, Esmat Aghadavod
Q2.2 — Are there concerns relating to the timing or absence of study registration?
Rationale: Study was registered after recruitment started
Supporting Evidence (2)
Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)
Registration ID: IRCT201605215623N79
Registry: IRCT
Registry Link: https://trialsearch.who.int/Trial2.aspx?TrialID=IRCT201605215623N79 (opens in new tab)
Registration Date: 25 May 2016
Prospective:Whether the trial was registered before participant recruitment began No
Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates Comparison performed at month level. Registration: 2016-05, LLM Recruitment Start: 2016-03. Deemed retrospective at month level.
Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text
Recruitment Start: 03-2016
Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date The study was performed between March 2016 and June 2016. Using start of conducted range as recruitment_start per rule 5; no specific FPI elsewhere.
Recruitment End: N/A
Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date No explicit end-of-recruitment date after full search.
Study End: 06-2016
Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date The study was performed between March 2016 and June 2016. Using end of conducted range as study_end_date per rule 5; no specific completion date.
Overall — What is the overall integrity assessment of the study?
Rationale: Serious concerns in 1.2, 1.3 and 2.1