Effect of Folate and Mecobalamin on Hip Fractures in Patients With Stroke
Assessed by RV013 · Clinical Chair in Health Services Research
Assessed on 13 Nov 2025
OverallReviewer's overall integrity assessment, derived from all research questions Serious concerns
Resource ripekg:research-integrity-assessment/RIPEA02C7C24523188961
5 Research Questions · 75 Evidence Items
Q1.1 — Does the study have an associated retraction?
Rationale: Journal webpage has retraction. Reference list check seems to have failed
Supporting Evidence (5)
Retraction NoticeSource: Retraction Watch database
Development of Osteopenia in the Hemiplegic Finger in Patients with Stroke
10.1159/000485018 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 17309
Rationale: Falsification/Fabrication of Data;Investigation by Company/Institution;Investigation by Third Party;Misconduct - Official Investigation(s) and/or Finding(s);Misconduct by Author
Retraction NoticeSource: Retraction Watch database
Vitamin D deficiency and risk of hip fractures among disabled elderly stroke patients
10.1161/str.0000000000000201 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 20921
Rationale: Investigation by Company/Institution;Lack of IRB/IACUC Approval and/or Compliance;Upgrade/Update of Prior Notice(s)
Retraction NoticeSource: Retraction Watch database
Hyperhomocysteinemia in Japanese patients with convalescent stage ischemic stroke: Effect of combined therapy with folic acid and mecobalamine
10.1016/j.jns.2023.122820 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 50210
Rationale: Concerns/Issues About Authorship/Affiliation;Concerns/Issues About Data;Falsification/Fabrication of Data;Investigation by Journal/Publisher;Unreliable Results and/or Conclusions
About Authors: Yoshihiro Sato, Kei Satoh
Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?
Rationale: EoC on RW
Q1.3 — Do other studies by the research team highlight causes for concern?
Rationale: Yes, multiple problems
Supporting Evidence (68)
Retraction NoticeSource: Retraction Watch database
Risedronate Therapy for Prevention of Hip Fracture After Stroke in Elderly Women. Reply to Authors
10.1212/wnl.0000000000002788 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 10303
Rationale: False/Forged Authorship;Misconduct by Author;Unreliable Results and/or Conclusions
About Author: Tomohiro Kanoko
Retraction NoticeSource: Retraction Watch database
Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial
10.1001/jama.2017.10705 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 10309
Rationale: Cites Retracted Work
About Author: Tomohiro Kanoko
Retraction NoticeSource: Retraction Watch database
Beneficial Effect of Etidronate Therapy in Immobilized Hip Fracture Patients
10.1097/phm.0000000000000822 (opens in new tab)RetractionWatch ID:Record identifier in the Retraction Watch database 11839
Rationale: Concerns/Issues About Data;Concerns/Issues about Results and/or Conclusions;Investigation by Company/Institution;Investigation by Journal/Publisher;Updated to Retraction
About Author: Tomohiro Kanoko
Q2.2 — Are there concerns relating to the timing or absence of study registration?
Rationale: Not registered, but registration didn't start until 2005.
Supporting Evidence (2)
Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)
No trial registration found
Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates Registry registration date (study_first_submit_qc_date) is missing or empty.
Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text
Recruitment Start: 01-04-2000
Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date Patients were recruited from April 1, 2000, to May 31, 2001.
Recruitment End: 31-05-2001
Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date Patients were recruited from April 1, 2000, to May 31, 2001.
Study End: N/A
Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date The follow-up occurred until May 30, 2003, but there is no explicit mention of study completion, so the follow-up date is not used.
Overall — What is the overall integrity assessment of the study?
Rationale: As a result of retraction, EoC and authors