Human cold pain: a randomized crossover trial

Assessed by RV014 · Research Fellow

Assessed on 5 Nov 2025

OverallReviewer's overall integrity assessment, derived from all research questions No concerns

DOI 10.1097/j.pain.0000000000003503 (opens in new tab)

Resource ripekg:research-integrity-assessment/RIPEA00C7F305EF5555AE

5 Research Questions · 2 Evidence Items

Q1.1 — Does the study have an associated retraction?

Automated Assessment:Assessment produced by the automated systemNo

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsNo

Rationale: I agree with INSPECT-AI

Q1.2 — Does the study have an associated expression of concern or other relevant post-publication notice?

Automated Assessment:Assessment produced by the automated systemNo

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsNo

Rationale: I agree with INSPECT-AI

Q1.3 — Do other studies by the research team highlight causes for concern?

Automated Assessment:Assessment produced by the automated systemNo

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsNo

Rationale: I agree with INSPECT-AI

Q2.2 — Are there concerns relating to the timing or absence of study registration?

Automated Assessment:Assessment produced by the automated systemNo

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsNo

Rationale: I agree with INSPECT-AI

Supporting Evidence (2)

Clinical Trial RegistrationSource: Clinical trial registry (e.g. ClinicalTrials.gov, ISRCTN)

Registration ID: NCT05935280

Registry: ClinicalTrials.gov

Registry Link: https://clinicaltrials.gov/study/NCT05935280 (opens in new tab)

Registration Date: 06-07-2023

Prospective:Whether the trial was registered before participant recruitment began Yes

Assessment Rationale:How INSPECT-AI determined the prospective registration status by comparing dates Registration date is on or before LLM recruitment start date.

Study Design EvidenceDates and timelines extracted by INSPECT-AI from the publication text

Recruitment Start: 07-07-2023

Recruitment Start Rationale:INSPECT-AI's reasoning for how it identified the recruitment start date Results: 'The first participant was included on July 7, 2023'.

Recruitment End: 01-09-2023

Recruitment End Rationale:INSPECT-AI's reasoning for how it identified the recruitment end date Results: 'and the 36th participant on September 1, 2023'.

Study End: 01-09-2023

Study End Rationale:INSPECT-AI's reasoning for how it identified the study end date Results: 'The trial ended when the target sample size of 36 was reached' which was on 01-09-2023.

Overall — What is the overall integrity assessment of the study?

Automated Assessment:Assessment produced by the automated systemN/A

Human Assessment:Assessment by a domain expert reviewer, informed by AI resultsNo concerns

Rationale: No integrity concerns based on these checks